Household pets are the most common source of allergic reactions to animals.

Many people think that pet allergy is provoked by the fur of cats and dogs. Researchers have found, however, that the major allergens are proteins in the saliva. These proteins stick to the fur when the animal licks itself. Urine is also a source of allergy-causing proteins, as is the skin. When the substance carrying the proteins dries, the proteins can then float into the air. Cats may be more likely than dogs to cause allergic reactions because they lick themselves more, may be held more, and spend more time in the house, close to humans. Some rodents, such as guinea pigs and gerbils, have become increasingly popular as household pets. They, too, can cause allergic reactions in some people, as can mice and rats. Urine is the major source of allergens from these animals.

Allergies to animals can take 2 years or more to develop and may not decrease until 6 months or more after ending contact with the animal. Carpet and furniture are a reservoir for pet allergens, and the allergens can remain in them for 4 to 6 weeks. In addition, these allergens can stay in household air for months after the animal has been removed. Therefore, it is wise for people with an animal allergy to check with the landlord or previous owner to find out if furry pets lived on the premises.